Ten Outliers Revolutionizing Health and Medicine

OneSkin

How undead is your skin? Scientists have a fun term for the cellular process which causes aging:  “zombie cells”, referring to the damaged cells which stop dividing and instead linger in your skin, where they sag, thin, and grow dull, leading to wrinkles and other typical signs of age. 

Most of the so-called anti-aging products on the market treat the surface of our skin and can’t do anything to stop this internal, biological process. But in 2016, four Brazilian female PhDs arrived in a San Francisco biotech to upend the game. They spent years screening hundreds of peptides, which act as biological messengers, in the hunt for ones which might slow or reverse cellular aging, before finding a sequence which seemed to reduce these age markings. They converted it into a moisturizer. The rest is history.

OneSkin — the company created by co-founders Carolina Reis Oliveira and Alessandra Zonari, who became Endeavor Entrepreneurs in 2024 — is now beloved by celebrities like Jennifer Aniston and Matthew McConaughey, Silicon Valley locals like XPRIZE founder Peter Diamandis and serial entrepreneur Kevin Rose, and thousands of customers alike. In August last year, they announced their $20M Series A, breaking barriers in both entrepreneurship and STEM — two fields where women are typically underrepresented. And they’re bringing rigorous scientific process back into an industry that tends to fudge its research. 

Standouts, but not singular: That’s the throughline in Endeavor’s Outlier program, which celebrates and supports the best-in-class companies in Endeavor’s portfolio. OneSkin first became an Outlier in 2025. But they’re not the only company changing the ways we take care of our health. 

“Outliers like OneSkin and Watchmaker Genomics excite us because they offer innovative scientific progress coming from unexpected places. But it’s also interesting to watch other companies using tech to offer greater access and healthcare at scale, like Alice covering a massive infrastructure gap in Brazil, or Sondermind and Unobravo offering affordable and accessible mental health support.”

Here are nine other companies making their mark in health and medicine.

Watchmaker Genomics

Genomics — the study of DNA, RNA, and epigenetic information — helps researchers understand diseases on a molecular level, leading to everything from improved cancer treatment to disease prevention and prediction. But to study genomics, researchers’ diagnostic workflows require enzymes which determine the accuracy and reliability of the resulting data. Improve the enzymes, and you improve the diagnostic test.

That’s where Watchmaker Genomics comes in. Inspired by his grandfather’s entrepreneurial work in telecommunications and his own passion for biotechnology, Trey Foskett (who became an Endeavor Entrepreneur in 2025) co-founded Watchmaker Genomics to supply the genomics sector with high-performance enzymes purpose-built for clinical samples. As a result, labs get more accurate and comprehensive molecular information from every test. After a $40M Series A in 2022, the company has continued to grow, launching new technology that unites genetic and epigenetic readouts from the same DNA molecule and expanding its team in the US, South Africa, Europe, and China. 

This is Watchmaker Genomics’ first year as an Outlier.

Sondermind

Mental health has long been a field plagued by accessibility issues: lack of awareness, lack of treatment, lack of affordable options. Since CEO and Founder Mark Frank launched Sondermind in 2017, partially inspired by his experience in the military and his fellow soldiers suffering from PTSD, the company has been working to change this, connecting providers with patients via a frictionless platform that allows therapists to accept insurance with a guaranteed 24-hour reimbursement.

The advent of AI has only boosted Sondermind’s ability to make strides in the field. The company’s AI Notes tool helps providers transcribe and format clients’ notes (with consent), generating over 100,000 notes for insurance claim submission and saving providers up to 90 minutes per day. Mark became an Endeavor Entrepreneur and an Outlier in 2020.

Numan

Men’s health issues are a significant and global problem: across every country, men die younger than women, and studies in both Europe and Australia show that men are less likely to seek regular health check-ups and more likely to die from preventable causes. Stigma can make it even harder for men to follow up on issues, including erectile dysfunction, hair loss, weight loss, premature ejaculation, testosterone optimization, and sleep.

UK-based digital healthcare provider Numan is changing this with a unique approach. Rather than focusing on access and convenience, like most digital health solutions, Numan focuses on preventative care, offering diagnostics, medications, behavioral coaching, and expert guidance in its all-in-one platform to stop health conditions from becoming chronic.

In 2023, Numan Founder Sokratis Papafloratos became an Endeavor Entrepreneur, then led the company to revenues of $90M in 2024 — more than doubling its year-on-year figures. In 2025, Numan announced a $60M Series B, allowing it to double down on its offer… and expand the platform to women, too. The same year, Numan became an Outlier for the first time.

DocPlanner

In 2012, serial entrepreneur Mariusz Gralewski became frustrated with the difficulty in finding specialist doctors in his home country of Poland. He acquired a small Polish doctor review website called ZnanyLekarz and added a booking functionality. Then he began to expand.

Today, DocPlanner connects 100 million monthly users with 2.8 million medical professionals. One of the world’s largest healthcare digital platforms, DocPlanner has raised $590M and was one of the first Polish unicorns, valued today at up to $3.6B, with more than 3,000 employees across Europe and Latin America.

Mariusz has laid out his plans to expand the company’s AI offering, with automated documentation and a prescription feature. Mariusz became an Endeavor Entrepreneur in 2025 and unlocked Outlier status the same year.

Impress

At this year’s Winter Olympics in Milan, as the gold-medal-winning figure skater Alysa Liu beamed during her victory lap around the ice, her smile meant something extra to the team at Impress, founded in Barcelona in 2019. She was once one of their patients. 

Impress transforms orthopedic care via their clear aligner treatments in 110 clinics across 10 countries in Europe and the United States. Co-founded by husband-and-wife team Vladimir and Dilara Lupenko (who became Endeavor Entrepreneurs in 2022) alongside Chief Orthodontist Khaled Kasem, Impress combines proprietary software with rigorous clinical oversight. The result has been orthodontic treatment for over 250,000 patients and, most recently, a ~$125M (€110M) funding round. Impress has been an Outlier since 2023.

Unobravo

In 2017, Danila de Stefano completed a Master’s in clinical psychology in Rome and moved to London, working in the research team at the University of London’s psychology and psychiatry departments. In the midst of the transition and driven by her own belief that everyone should have access to a psychologist, she began looking for her own psychologist — and found that, despite the high number of Italian expats in London, affordable and personalized care in her native language was next to impossible. If she was struggling, with all her professional connections and expertise in the field, how about everyone else?

Danila began offering therapy services online, and when demand boomed, she realized the company could be much more, and founded Unobravo in 2019. With a $17M Series A in 2022, Unobravo expanded rapidly and the same year, Danila and her co-founder, Gregorio Maria Diodovich, became Endeavor Entrepreneurs. In 2023, Unobravo became an Outlier for the first time and today, the company has supported 400,000 patients through more than seven million sessions.

Buymed

Vietnam’s pharmaceutical industry was fragmented and disorganized, full of noncompliance issues and inefficiencies. But because it was “the way it had always been done”, online pharmaceutical marketplace Buymed (founded in 2018) had trouble convincing stakeholders of its necessity — until COVID hit. Delivering medicine to pharmacies, clinics, and hospitals across the country during lockdown demonstrated the company’s value, and today the company has built a reach into 12,000 townships across Vietnam.

Investors saw the company’s potential too. Buymed raised a $8.8M Series A in 2021, followed by a $51.5MM Series B in 2023. Co-founder and CEO Hoang Nguyen became an Endeavor Entrepreneur in 2024, and the company was first chosen as an Outlier in 2025.

Alice

In Brazil, Cesarean sections account for 58% of all deliveries during birth, one of the highest rates in the world, and more than four times what the World Health Organization says reflects a “normal” rate for births. One unexpected source of change has come from Alice, a private health insurer that doesn’t just issue healthcare insurance policies. Instead, the team at Alice has developed a virtual-first primary-care system that both lowers costs and offers better outcomes for its patients, with specialist teams including gynecologists and midwives. And it worked: year-over-year, vaginal births amongst Alice patients went from 20% to 70%.

Alice isn’t just for pregnancy and birth. The health tech company led by co-founders Andre Florence Carneiro, Guilherme Teixeira Azevedo, and Matheus Hermsdorff Moraes (who became Endeavor Entrepreneurs in 2022) uses its primary care technology to enhance health outcomes for all patients. In 2021, Alice announced a $127M Series C led by Softbank and in 2023, the company became an Outlier for the first time.

Abarca Health

When he was 16 years old, Jason Borschow started work at the drug and medical supply company founded by his grandfather in 1951 and later scaled by his parents. He then moved overseas to study economics at Harvard and work in management consulting in New York City and Australia, before returning to Puerto Rico to help his parents run and ultimately sell the family business to Cardinal Health, a Fortune 20 company, in late 2008. 

And then Jason had a choice: Move back to New York, or stay in Puerto Rico and pursue his entrepreneurial DNA? He chose the latter, founding the company that became Abarca Health in 2010. A pharmacy benefit manager and healthcare technology company, Abarca operates from Puerto Rico across the United States to improve the pharmacy and healthcare experience. An Endeavor Entrepreneur since 2018, Jason led his company to become an Outlier for the first time in 2020.

Discover the full class of companies building the future from Elsewhere. Meet the 2026 Endeavor Outliers class.